1,2-Dichloroethane (Ethylene Dichloride) 107-06-2 Hazard Summary

EPA Office of Air Quality Planning and Standards, Technology Transfer Network 17may01

CAUTION: Unless otherwise noted, the quantitative information on these fact sheets are from "EPA Health Effects Notebook for Hazardous Air Pollutants-Draft", EPA-452/D-95-00, PB95-503579, December 1994." Please conduct a current literature search and check the appropriate current online database for the most recent quantitative information.


a The 1/ED10 value is a measure of the carcinogenic potency of a chemical. The value reported here has been proposed in the hazard ranking of hazardous air pollutants in EPA's proposed rulemaking (Section 112(g) of the Clean Air Act, April 1994).

Please Note: The main sources of information for this fact sheet are EPA's Integrated Risk Information System (IRIS), which contains information on the carcinogenic effects of 1,2-dichloroethane including the unit cancer risk for inhalation exposure, and the Agency for Toxic Substances and Disease Registry's (ATSDR's) Toxicological Profile for 1,2-Dichloroethane. Other secondary sources include Hazardous Substances Data Bank (HSDB), a database of summaries of peer-reviewed literature, and the Registry of Toxic Effects of Chemical Substances (RTECS), a database of toxic effects that are not peer reviewed.

Environmental/Occupational Exposure

Assessing Personal Exposure

Health Hazard Information


Acute Effects:
Chronic Effects (Noncancer):
Reproductive/Developmental Effects:
Cancer Risk:

Physical Properties

Uses



Conversion Factors:
To convert from ppm to mg/m3: mg/m3 = (ppm) × (molecular weight of the compound)/(24.45). For 1,2-dichloroethane: 1 ppm = 4.05 mg/m3.

Health Data from Inhalation Exposure

Concentration
(mg/m3)

Health numbersa

Regulatory, advisory numbersb

Reference

10,000.0

1,000.0

  • LC50 in rats
    (4,047 mg/m3)


2

100.0

  • MSHA standard (200 mg/m3)

2

10.0

  • ACGIH TLV (40 mg/m3)

2

1.0

  • NIOSH REL and OSHA PEL
    (4 mg/m3)

2

0.1

0.01

0.001

0.0001

0.00001

  • EPA Cancer Risk Levelc (1 in-a-million excess lifetime risk) = 0.00004 mg/m3


3


See notes on the following page.
ACGIH TLV--American Conference of Governmental and Industrial Hygienists' threshold limit value expressed as a time-weighted average; the concentration of a substance to which most workers can be exposed without adverse effects.
LC50 (Lethal Concentration50)--A calculated concentration of a chemical in air to which exposure for a specific length of time is expected to cause death in 50% of a defined experimental animal population.
MSHA--Mine Safety and Health Administration.
NIOSH REL--National Institute of Occupational Safety and Health recommended exposure limit; NIOSH-recommended exposure limit for an 8- or 10-h time-weighted-average exposure and/or ceiling.
OSHA PEL--Occupational Safety and Health Administration's permissible exposure limit expressed as a time-weighted average; the concentration of a substance to which most workers can be exposed without adverse effect averaged over a normal 8-h workday or a 40-h workweek.

a Health numbers are toxicological numbers from animal testing or risk assessment values developed by EPA.
b Regulatory numbers are values that have been incorporated in Government regulations, while advisory numbers are nonregulatory values provided by the Government or other groups as advice.
c These cancer risk estimates were derived from oral data and converted to provide the estimated inhalation risk.

References

  1. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for 1,2-Dichloroethane (Draft). U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. 1993.
  2. U.S. Department of Health and Human Services. Registry of Toxic Effects of Chemical Substances (RTECS, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
  3. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS) on 1,2-Dichloroethane. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1993.
  4. U.S. Environmental Protection Agency. Health and Environmental Effects Profile for Dichloroethanes. EPA/600/x-85/359. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1985.
  5. International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Some Halogenated Hydrocarbons. Volume 20. World Health Organization, Lyon. 1979.
  6. U.S. Environmental Protection Agency. Health Effects Assessment for 1,2-Dichloroethane. EPA/540/1-86/002. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1986.
  7. U.S. Environmental Protection Agency. Technical Background Document to Support Rulemaking Pursuant to the Clean Air Act--Section 112(g). Ranking of Pollutants with Respect to Hazard to Human Health. EPA­450/3-92-010. Emissions Standards Division, Office of Air Quality Planning and Standards, Research Triangle Park, NC. 1994.

1. *Micrograms per cubic meter is the unit of measurement for chemicals in air.

Last updated May 17, 2001
source: http://www.epa.gov/ttn/uatw/hlthef/di-ethan.html 24nov01

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