EPA is proposing to add a diisononyl phthalate (DINP) category to the list of toxic chemicals included in the annual Toxics Release Inventory (TRI) reporting. The proposal is in response to a petition by the Washington Toxics Coalition which contends that DINP causes cancer, systemic toxicity, developmental toxicity, and endocrine disruption. EPA reviewed the petition and available data and preliminarily determined that DINP meets the listing criteria and that there is sufficient evidence that chemicals in the DINP category can reasonably be anticipated to cause cancer or other serious or irreversible chronic liver, kidney, or developmental toxicity in humans. The listing is proposed under section 313 of the Emergency Planning and Community Right-to-Know Act. The proposed rule was published in the Federal Register on Sept. 5, 2000. Comments must be received by EPA on or before Dec. 4, 2000. For technical information on the proposed rule, contact Daniel R. Bushman, EPA (MC 2844), 1200 Pennsylvania Ave., N.W., Washington, D.C. 20460; telephone 202-260-3882; e-mail address: bushman.daniel@epa.gov Electronic| copies of the proposal can be obtained at: http://www.epa.gov/tri Print copies can be obtained by calling the Emergency Planning and Community Right to Know hotline at: 1-800-535-0202
DIISONONYL PHTHALATE
Human Health Effects:
Human Toxicity Excerpts:
... A central nervous depressant if absorbed. /Phthalic acid esters/
[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial
Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-204]**PEER
REVIEWED**
... The phthalates represent one of the lowest toxicity classes used in
industry. /Phthalates/
[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and
Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY:
John Wiley & Sons Inc., 1993-1994. 3047]**PEER REVIEWED**
The acute toxicity of phthalates is very slight and decreases generally with
the increasing molecular weight. /Phthalates/
[International Labour Office. Encyclopedia of Occupational Health and
Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983.
1691]**PEER REVIEWED**
Probable Routes of Human Exposure:
NIOSH (NOES Survey 1981-1983) has statistically estimated that 31,088 workers
(9,675 of these are female) are potentially exposed to diisononyl phthalate in
the US(1). Occupational exposure may be through inhalation and dermal contact
with this compound at workplaces where this compound is produced or used(SRC).
[(1) NIOSH; National Occupational Exposure Survey (NOES) (1983)]**PEER
REVIEWED**
Synonyms:
1,2-BENZENEDICARBOXYLIC ACID, DIISONONYL ESTER
DINP
ENJ 2065
Palatinol N
PALATINOL DN
PHTHALIC ACID, DIISONONYL ESTER
Sansocizer DINP
Vestinol NN
WITAMOL 150
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