In her Dec. 12 editorial-page commentary, American Council on Science and Health President Elizabeth Whelan claims there is no link between cancer and PCBs now contaminating the Hudson River.
On the contrary, there are a number of independent studies linking PCBs with cancer in humans, as well as to neurological damage to developing fetuses and children. PCBs are considered so dangerous that they were among the first 12 chemicals to be eliminated world-wide in the just-finalized international treaty on persistent organic pollutants. While the U.S. EPA, the National Toxicology Program and the International Agency for Research on Cancer all consider PCBs to be a "probable human carcinogen," PCBs are a known endocrine disruptor -- interfering with natural hormone system development and function.
There is significant peer-reviewed literature documenting the effects of PCBs on wildlife, laboratory animals, and more recently on children whose mothers had PCB concentrations during pregnancy at or below levels typical for most Americans. (Agency for Toxic Substances and Disease Registry, Centers for Disease Control, 1998.)
PCBs are persistent -- they do not break down easily in the environment. They also bio-accumulate up the food chain and therefore are found in higher concentrations in carnivores at the top. A serious public health concern today is the large amount of persistent organic pollutants, including PCBs, found in human breast milk.
David O. Carpenter, M.D.
Professor, Environmental Health and Toxicology
School of Public Health
SUNY at Albany
Rensselaer, N.Y.
By Elizabeth M. Whelan, president of the American Council on Science and Health.
Last week the Environmental Protection Agency proposed that General Electric spend $490 million dredging the Hudson River to remove what are known as polychlorinated biphenyls, or PCBs.
Until 1977, PCBs were used in the manufacture of transformers, adhesives and capacitators, among other things. GE legally dumped them into the river north of Albany for decades. The PCBs are now embedded in the mud beneath the Hudson, and are not generally dispersed in the water.Media coverage has been murky as to exactly what the EPA hopes to accomplish with half a billion dollars of dredging. To clarify the agency's intent, I contacted EPA official Kevin Matthews. He explained that the EPA was worried about both the "health of the river" and about human health problems, particularly an increased risk of cancer from eating Hudson River fish.
But contrary to EPA assertions, there is no credible evidence that PCB exposure in the general environment, in fish, or even at very high levels in the workplace, has ever led to an increase in cancer risk. While reasonable people have suggested that dredging would displace buried PCBs and make matters worse, at this point we have no evidence that even high-level human exposure to PCBs causes any problem other than eye and skin irritation.
The EPA's assertion that PCBs in fish pose a human cancer risk is based solely on observations that high-dose, prolonged PCB exposure causes tumors in laboratory animals. But this is very different from the question at hand: Is there any evidence that the traces of PCBs in Hudson River fish increase the risk of cancer in humans? The EPA, an environmental regulatory agency, isn't known for its competency in the scientific discipline of cancer causation. We therefore need to turn elsewhere for expert opinions on any causal relationship between PCBs and cancer.
An examination of the bible of cancer causation, "Cancer Epidemiology and Prevention" by David Schottenfeld and Joseph F. Fraumeni Jr., reveals no reference whatsoever to PCB-containing fish (or any other source of PCBs) causing malignancy. This 1,500-page volume focuses on real human cancer risks, like tobacco use and overexposure to sunlight. But perhaps the ultimate authority on cancer risk is the National Cancer Institute. I put the question to the institute's director, Richard Klausner: Does NCI have any evidence that eating fish from the Hudson River contributes to the toll of human cancer?
This wasn't the first time I'd queried Dr. Klausner on cancer causation. Over two years ago the organization I head up, the American Council on Science and Health, composed (and had peer-reviewed) a similar, but broader, question for which we unanimously agreed the answer was no. (ACSH is an independent consortium of 350 physicians and scientists, funded by private foundations and corporations, including the GE fund, which accounts for about 1% of the group's total budget.)
Specifically, we asked Dr. Klausner: "At this time, does the NCI know of any credible scientific evidence that exposure to trace levels (parts per million or less) of synthetic chemicals in the general environment -- even if these chemicals have been shown in high dose to cause cancer in laboratory animals -- contributes to the toll of human cancer in the U.S.?"
As should now be obvious to GE and every other U.S. manufacturer, this is much more than a theoretical question. It has immediate, practical and costly implications. Congress, for example, has passed laws based on the premise that a "mouse is a little man." One, the "Delaney Clause," states unequivocally that any synthetic food chemical that causes cancer in lab animals must be assumed to pose a human cancer risk -- no matter how minimal the human exposure -- and must be banned. Similarly, California's Proposition 65 requires that all consumer products containing even trace levels of animal carcinogens be banned or labeled. In short, decisions are being made, and limited resources are being committed, based on the assumption that trace exposures to animal carcinogens like PCBs pose a human cancer risk and must not be tolerated, no matter what the cost.
For over two years, NCI has refused to answer our original question. Presumably NCI has been resisting stating the obvious -- that there is no evidence that trace levels of animal carcinogens pose a human cancer risk -- to avoid a head-on collision with the EPA, which for decades has been on a regulatory carcinogen witch hunt.
This week, however, the National Cancer Institute found its voice. Susan Sieber, a scientist and director of communications, told me that the institute knew of "no evidence" that eating fish from the Hudson River posed a human cancer risk. Why should we tolerate government policies that purport to prevent cancer by targeting environmental risks our nation's top cancer experts say don't exist?
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