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The teratogenic potential of the herbicide
glyphosate-Roundup® in Wistar rats

Toxicology Letters v.142, i.1-2, 30apr03

Eliane Dallegrave*,a Fabiana DiGiorgio Mantesea, Ricardo Soares Coelhoa, Janaína Drawans Pereiraa, Paulo Roberto Dalsenterb and Augusto Langeloha

a Department of Pharmacology, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Sarmento Leite 500 sala 202, 90046-900, Porto Alegre, RS, Brazil b Department of Pharmacology, Instituto de Ciências Biológicas, Centro Politécnico, Universidade Federal do Paraná, Curitiba, PR, Brazil

Received 13 September 2002; revised 9 December 2002; accepted 10 December 2002. ; Available online 8 February 2003.


The aim of this study was to assess the teratogenicity of the herbicide glyphosate-Roundup® (as commercialized in Brazil) to Wistar rats. Dams were treated orally with water or 500, 750 or 1000 mg/kg glyphosate from day 6 to 15 of pregnancy. Cesarean sections were performed on day 21 of pregnancy, and number of corpora lutea, implantation sites, living and dead fetuses, and resorptions were recorded. Weight and gender of the fetuses were determined, and fetuses were examined for external malformations and skeletal alterations. The organs of the dams were removed and weighed. Results showed a 50% mortality rate for dams treated with 1000 mg/kg glyphosate. Skeletal alterations were observed in 15.4, 33.1, 42.0 and 57.3% of fetuses from the control, 500, 750 and 1000 mg/kg glyphosate groups, respectively. We may conclude that glyphosate-Roundup® is toxic to the dams and induces developmental retardation of the fetal skeleton.

Author Keywords: Teratogenicity; Herbicide-Roundup®; Glyphosate; Polyoxyethyleneamine; Rats; Skeletal alterations

* Corresponding author. Tel.: +55-51-3316-3183; fax: +55-51-3316-3121 elianed@vortex.ufrgs.br

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