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Exploring Natural Solutions For Attention Deficit Hyperactivity Disorder
Raymond M. Lombardi, ND, DC, CCN / Delicious Living Nov00

Childhood should be a special time, a sojourn filled with wonder, curiosity, fun and growth.

While this maybe true for many, an increasing number of children are being diagnosed with a variety of behavioral problems ranging from mildly disruptive behavior to serious disorders such as autism. Of the many chronic childhood illnesses that wreak havoc on both child and family, one has reached alarming levels: attention deficit hyperactivity disorder (ADHD).

ADHD is being identified as epidemic throughout the United States. The National Institutes of Health in Washington, D.C., estimates that from 3 percent to 5 percent of all American schoolchildren have been diagnosed with the disorder. It is not uncommon to see a line of children standing outside the nurse's office at school awaiting their midday dose of Ritalin. This trend alone is reason for concern. Besides the physiological issues behind the diagnosis, the emotional consequences of ADHD - children aren't doing well in school, parents and teachers are frustrated, families are disrupted - drive the search for a cure. In the desire to solve these issues, more than 6 million American children currently diagnosed with ADHD are being treated with central nervous system stimulants - usually methylphenidate (Ritalin).

This relatively new diagnosis, as well as treatment for it, is not based on long-term studies, and parents are given few options but Ritalin. Before turning to drugs, however, there are some gentle, natural options to consider.

The American Psychiatric Association, based in Washington, D.C., describes ADHD as a disorder whose main features include "hyperactivity, impulsiveness and an inability to sustain attention or concentration." In simple terms, ADHD can be characterized by two distinct sets of symptoms -inattention and hyperactivity. ADHD is further divided into three specific diagnostic forms, each based on a specific clinical presentation that seeks to better describe a child's behaviors. These forms are ADHD-Primarily Inattentive Type (sometimes called simply ADD, attention deficit disorder); ADHD-Primarily Hyperactive/Impulsive Type; and ADHD-Combined Type (a combination of inattentive and hyperactive).

Regardless of the categories defined for ADHD, it remains an elusive and difficult disorder to diagnose. No specific medical laboratory markers exist for ADHD, and the diagnosis is usually based on behavioral assessment tests, observations from parents and teachers and clinical assessments from health care providers. Consequently, the diagnosis comes from subjective analysis.

The extreme variation in diagnosing true ADHD patterns was shown in a recent study performed by researchers at the Center for Pediatric Research at Eastern Virginia Medical School in Norfolk who evaluated the extent of ADHD medication use. Students enrolled in grades two through five in the school districts in two cities (5,767 students in district A and 23,967 students in district B) were evaluated based on nurse records of those receiving ADHD medication in school. The prevalence of ADHD was 12 percent in district A and 63 percent in district B. The researchers concluded that the criteria for ADHD diagnosis varies substantially across U.S. populations, with potential over-diagnosis and over-treatment of ADHD in some groups of children (American Journal of Public Health, 1999, vol. 89). In an attempt to provide definition for diagnosis, the American Academy of Pediatrics issued its first ADHD guidelines in May (see www.aap.org for details).

WHAT SHOULD I TAKE
                       and how much?
SUGGESTED ADHD
SUPPLIMENTS
DOSAGE
VITAMIN 131 100--300 mg/day
VITAMIN B3 100-300 mg/day
VITAMIN B5 100-300 mg/day
VITAMIN B6 100-300 mg/day
VITAMIN B12 1,000-2,500 mcg/day
FOLIC ACID 800-1,200 mcg/day
GAGA
(B complex capsule recommended)
100 mg/day
VITAMIN C 1,000-2,500 mg/day
VITAMIN E 400--g001U/day
CALCIUM 500-1,000 mg/day
IRON 10-30 mg/day
MAGNESIUM 100-200 mg/day
ZINC 10-30 mg/day
5-HTP 50 mg/day
TAURINE 100 mg/day
L-TYROSINE 100 mg/day
L-GLUTAMINE 100 mg/day
DL-PHENYLALANINE
(Amino acid complex recommended)
100 mg/day
DMG
(Dimethiyglycine)
As directed on bottle
LECITHIN
(with phosphatidycholine and inositol)
3-5 grams/day
DMAE
(Dimethylaminoethanol)
100-300 mg/day
PROANTHOCYANIDINS As directed on bottle
EFAS (omega-3 and -6) 1,000-2,000 mg/day
Source: Leo Galland, M.D., "ADHD: Causes and Possible Solutions;" conference, November 4-7,1999, Arlington, Va.

A number of primary and secondary mechanisms have been proposed as causes of or influences on ADHD. These include possible brain dysfunction (ranging from difficulties with information transfer to brain chemistry neurotransmitter deficits); genetic influences (a family history of ADHD greatly increases the risk); environmental toxins such as lead, alcohol and cigarette smoke; food additives and coloring; food allergies; and nutrient depletions.

Traditional Western medicine utilizes stimulant and depressive medications, as well as behavioral modifications, as primary treatment modes. However, given the many potential causes of ADHD, specifically addressing the relevant probable factors can be critical to establishing an appropriate treatment regimen for an individual child. Approaches that lie outside of the traditional medical protocol include aromatherapy, biofeedback, Traditional Chinese Medicine, cranial-sacral therapy, flower essence remedies, homeopathy, hypnotherapy, massage therapy, and sound and vision therapy. However, nutritional and supplementation solutions for ADHD will be the two modalities explored here.

Food Fight
How important is the diet of an ADHD child? Very, according to a 1997 study published in the Journal of Pediatric Child Health. Author lean Breakey reviewed the most important research from 1985 to 1995 on the relationship between diet and behavior. She concluded that diet definitely affects some children and that symptoms relating to ADHD, such as sleeping problems, physical symptoms and mood changes, can change with diet (Journal of Pediatric Child Health, 1997, vol. 33).

It's important to understand that the body simply acts on the information it's given; if a child is sensitive to wheat, for example, the body is going to react accordingly. We may simply see it manifest as hyperactivity or an inability to focus.

However, dealing with the diet of an ADHD child can be difficult. Plus, corrective nutritional changes made at home can be usurped if a child eats the wrong foods at school, and vice versa.

Regardless, proper nutrition plays a critical role in modulating ADHD behavior.

The needed changes in diet can be addressed in a variety of ways. One way to begin nutritional changes is to institute an elimination or foodreduction diet. This type of diet, introduced in three stages, is used to reduce the number and types of food sources and can target artificial food colors and preservatives, limit foods that may be causing sensitivities and/or allergies and decrease sugar intake. Stage 1: A food elimination program is implemented by removing many foods

from the diet, such as junk foods; sugars; dairy products; whole grains like corn, barley and wheat; chocolate and other candy; citrus fruits; food colorings and additives. After elimination, unprocessed foods are reduced to basic items, such as specific fruits and vegetables only. The restricted, whole-food diet is kept in place a minimum of 8 to 12 weeks and the child's behavioral responses are observed.

Stage 2: At this point, a particular type of food - such as whole grains, citrus fruits, poultry or fish - is reintroduced. These whole foods are introduced individually and only one at a time. This "food loading" method allows observation of behavioral and personality changes in the child that can be associated with the inclusion of a specific food.

Stage 3: This final stage of the elimination diet establishes a long-term, whole food diet that is varied and tolerated by the child without causing negative physical and behavioral reactions.

In a 1999 report, the Washington, D.C.-based Center for Science in the Public Interest cited 17 controlled studies that found diet adversely affects some children's behavior, sometimes dramatically.

In 1997, researchers at Germany's Central Institute of Mental Health evaluated 49 children with hyperactive/ disruptive behavior disorder. This placebocontrolled, double-blind, crossover study comparing drugs to diet alone found "significant behavioral improvement" in 24 percent of the children who underwent dietary treatment. Although stimulant medications improved the condition in 44 percent of the children, researchers concluded that diet "cannot be neglected" in ADHD treatment (European Child and Adolescent Psychiatry, 1997, vol. 6).

A child's issue

DID YOU KNOW; Every school day at a specified time, children diagnosed with ADHD are required to leave class and go to the nurse's office for their midday dose of methylphenidate, commonly known at Ritalin. This disruption at school makes the issue a public one, often leaving a child embarrassed and stigmatized. Now a new form of the drug, called Concerta, developed by Crescendo Pharmaceuticals Corp, lasts 12 hours, rendering the midday dose unnecessary.

Like traditional doses of Ritalin, however, the drug doesn't come without a downside. The side effects reported from clinical trials included headaches (14 percent of patients), upper respiratory tract infections and stomachaches.

- The Associated Press, August 2, 2000

EFAs: the key to LD-FREE CHILDREN?

ESSENTIAL FATTY ACID (EFA) SUPPLEMENTATION FO R CHILDREN with ADHD and other learning disabilities (LDs) may be key in balancing brain chemistry and getting kids back on track. Authors B. Jacqueline Stordy, Ph.D., and Malcolm J. Nicholl explore this possibility in their new book The LCP Solution. The authors note studies showing 30 percent to 50 percent of dyslexic children and 50 percent of dyspraxic children have also been diagnosed with ADHD.

However, these three diagnoses are usually treated by different health care professionals, and often no correlation is made. Based on extensive research, the authors surmise, "... these specific learning disorders now appear to be associated with an inborn error of metabolism affecting the conversion of shorter chain EFAs into the longer chain polyunsaturated fatty acids (LCPs), and the incorporation of sufficient amounts of them into cell membranes. This leads to a deficiency of the LCPs, which are the keys to brain function, required for the normal, effective, rapid-fire communications between neurons."

- The lLCP Solution: The Remarkable Nutritional Treatment for ADHD, Dyslexia and Dyspraxia, Ballantine, 2000

Supplemental Help
Beyond the whole-food diet, a simple way of getting critical nutrients into an ADHD child is with supplements. The issues surrounding needed nutrient levels and supplementation in ADHD continues to be controversial, but research is increasing. The topic of nutritional supplementation was recently addressed by nutrition expert Leo Galland, M.D., at a 1999 conference on ADHD in Arlington, Va. Thailand presented information on the types of nutritional supplements that have been used in treating children with ADHD, as reported in published studies. Some of the supplements Galland discussed include certain B vitamins, essential fatty acids, magnesium, zinc, iron, amino acids, dimethylaminoethanol (DMAE), phosphatidylserine (PS) and oligosaccharides. The chart on page 42 ("What Should I Take, and How Much?") lists those nutrients Galland has found, in either his clinical practice or in the literature, to be beneficial for treating ADHD patients.

Essential Fatty Acids and their effects on ADHD behavior have been the subject of much recent research (see "EFAs: The Key to LD-Free Children?" p. 43). A 1995 study evaluated essential fatty acid metabolism in 96 boys, 53 with ADHD and 43 controls. The study found the ADHD subjects had significantly lower concentrations of omega-3 and omega-6 fatty acids in their blood plasma (American Journal of Clinical Nutrition, 1995, vol. 62).

Zinc levels also strongly correlate to ADHD patients. Psychiatry department researchers at Technical University in Turkey compared 48 ADHD children to 45 non-ADHD children. While free fatty acid levels in blood serum were nearly four times lower in ADHD children, mean serum zinc levels in ADHD patients were also less than half the levels of the children in the control group (Journal of Child Psychology and Psychiatry, 1996, vol. 37).

Magnesium and ADHD is another area of increasing interest. Researchers at the Department of Family Medicine in Szczecin, Poland, studied 116 ADHD children ages 9 to 12 for blood serum levels of magnesium. Remarkably, magnesium deficiency was found in 95 percent of those examined (Magnesium Research, 1997, vol. 10).

Iron helps regulate the activity of dopamine, a neurotransmitter synthesized by the adrenal glands and implicated in some forms of psychosis. Israeli researchers at Tel Aviv University evaluated 14 ADHD boys between the ages of 7 and 11 for the effect of short-term iron administration on behavior. Each boy received 5 mg/kg body weight of iron daily for 30 days. Both parents and teachers assessed their behavior according to the Connors Rating Scale, a psychological tool used in measuring behavior. Parents felt the children improved; their ratings dropped from 17.6 to 12.7. However, there was no change in the teachers' scores (Neuropsychobiology, 1997, vol. 35). Were these simply hopeful parents, or were the parents able to see changes the teachers could not? More studies are needed to determine the benefits of iron supplementation on ADHD children.

Serotonin levels may also affect ADHD patients. Researchers at Ness Zion Mental Health Center in Israel found serotonin blood levels tended to be lower in children with more severe markers of hyperactivity, impulsiveness, aggressiveness and lack of concentration (Acta Psychiatrica Scandinavica. 1999. vol. 99). Supplementation with 5-hydroxytryptophan (5-HTP), a serotonin precursor, may consequently help those with more severe ADHD symptoms.

More studies are needed to understand why ADHD-diagnosed children are depleted of certain nutrients. Absorption problems, metabolic problems or the diet itself may prove a culprit.

ADHD is a difficult disorder for all concerned - the child, family, parents and teachers. Current treatment focuses on standard medication as its primary model. But there are other, perhaps better, ways to deal with ADHD. One component perhaps the most critical component - to curing this nebulous malady may be nutrition: What foods do we allow our children to eat, and which supplements may ease their burden? Nutritional therapy, and a variety of other alternative care approaches, can be key to taming ADHD.

Raymond M. Lombardi, N.D., D.C., C.C.N., is a certified herbalist with an alternative care, holistic practice in Redding, Calif. He is author of Aspirin Alternatives - The Top Natural PainRelieving Analgesics (BL Publications).

Taking another look at the problem

THE ADHD DEBATE C0NTINUES : Is something physiologically wrong with these children, or are kids just being kids? A new study shows there may be a third, somewhat surprising, option worth considering. David Granet, Ph.D., director of pediatric ophthalmology at the University of CaliforniaSan Diego reviewed 1,700 records of children diagnosed with ADHD. He discovered that, of those who had taken eye exams, 16 percent had convergence insufficiency, an eye disorder that makes focusing on nearby targets difficult. This is three times the number of non-ADHD kids. More research is needed to determine if a brain impairment is causing both ADHD and the eye disorder, or if the eye disorder manifests the same symptoms as ADHD and causes misdiagnosis.

- American Academy of Pediatric Ophthalmology and Strabismus, proceedings, April I2-76, 2000

RITALIN: How Much is Too Much?

RITALIN IS A CENTRAL NERVOUS SYSTEM STIMULANT which, for reasons still not well understood, has a calming effect on the AND child. Knowing this, many issues need to be considered regarding these prescribed stimulant medications, including side effects, consequences of long-term use, abuse and overprescribing patterns due to mismanagement and misdiagnosis.

REVIEW OF SIDE EFFECTS COMMONLY ASSOCIATED WITH STIMULANT medication should be considered as more and more children are prescribed these potent psychoactive drugs. Some of Ritalin's documented side effects include anorexia, weight loss, irritability, abdominal pain, headaches, emotional oversensitivity, insomnia, depression, nervous habits, anxiety, impaired cognitive performance and psychotic symptoms (Pain & Stress Publications, 1996 report).

TWO RECENT STUDIES DISCUSSED SOME OF THESE SIDE EFFECTS In 1998, researchers studied sleep disturbances of AND children taking stimulant medication. They questioned parents of 20 AND children on stimulant medication, 20 unmedicated children with some psychiatric diagnosis (other than ADHD) and 20 nonclinical control children. The parents of the AND children reported significantly more problems with their children on settling and going to sleep, plus disruptions during sleep and morning activities (Journal of Clinical Psychology, 1998, vol. 54).

THE SECOND STUDY LOOKED AT THE PSYCHOTIC SIDE EFFECTS of these stimulants, a more serious issue. Researchers performed chart reviews over a five-year period at an outpatient clinic for all children diagnosed with AND who had been prescribed stimulant medication. Of 98 children, six developed psychotic or mood-congruent psychotic symptoms during treatment. They concluded that awareness of the potential for psychotic side effects from stimulant medications is important when prescribing for children (Canadian Journal of Psychiatry, 1999, vol. 44). - R.L. .

Adult ADHD

ADULTS CAN BE DIAGNOSED WITH ADHD, TOO. Evidence increasingly shows that children with ADHD can have persistent problems into adulthood, manifesting as adult ADHD (Nurse Practitioner, 1996, vol. 21). However, adult ADHD is poorly understood, making diagnosis difficult. As an aid in diagnosing adult ADHD, an important prerequisite is a history of childhood ADHD.

MANAGEMENT 0F ADULD ADHD is similar to that of childhood ADHD, with stimulant medications used as the primary treatment mode. However, only a limited number of controlled pharmacological studies have been conducted for this disorder (Journal of Clinical Psychopharmacology, 1999, vol. 19). The main stimulant medications used are pemoline, venlafaxine, desipramine, dexamphetamine and tomoxetine. Antidepressants are also employed.

AS WITH CHILDHOOD ADHD, limited research exists for the use and effectiveness of nutrition therapy and alternative care. However, those nutrient and alternative care therapies which have shown benefit for childhood ADHD can probably be applied to adult ADHD. While further investigation is desperately needed in this area, the lack of side effects and potential for symptom reduction is reason enough for adults diagnosed with ADHD to aggressively pursue these alternative approaches. - R.L.

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