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100 Molecular Millionaires

Genetic Engineering News 6dec00

If anyone has any doubts that biotechnology is poised to become one of the key industries of the 21st century, we offer the 2000 edition of our annual Genetic Engineering News’ 100 Molecular Millionaires as a rebuttal. This year’s listing contains a record dollar amount in the total value of biotech stock owned by the millionaires as well as an all-time high number of doctoral millionaires.

Having driven .com stocks to astronomical highs, investors began putting their money into biotech last year after they saw a market opportunity. A growing list of new product approvals and an increasing number of biotech products moving through clinical trials are changing the image of biotech as a collection of biotech boutiques into that of a "real" business.

Drug discovery, genomics and pharmacogenomics have become catchwords for investors. Their excitement, which continues to grow as they await completion of the first draft of the mapped human genome later this year, has propelled biotech stock values right through the roof. As a result, our listing of 100 molecular millionaires includes a record number of doctorates—96. This compares to 89 last year, 69 in 1998 and 72 in 1997.

William K. Bowes, Jr. is our top millionaire, with $686,398,793 of Amgen, XOMA and Lynx stock. The number one doctoral millionaire is Phillip Frost, M.D., with $642,434,166 of Ivax stock.

The value of the biotech/pharmaceutical stock held by all 100 of our millionaires this year totals a whopping $7.23 billion. This compares to $1.41 billion in 1999, $1.76 billion in 1998, $1.97 billion in 1997 and $2.05 billion in 1996.

The following have stock in more than one biotech company. William K. Bowes, Jr.—Amgen ($613,437,728), Lynx Therapeutics ($72,435,375) and Xoma ($525,690); Lindsay A. Rosenwald, M.D.—Avax Technologies ($16,194,690), Biocryst Pharmaceuticals (12,302,134), Genta ($270,370,463), Interneuron ($10,212,474) and Neose Technologies ($27,308,129); Joshua S. Boger, Ph.D.—Vertex ($2,270,483) and Millennium Pharmaceuticals ($11,455,554); Paul Schimmel, Ph.D.—Alkermes ($59,661,225) and Repligen (10,238,833); Frank Baldino, Jr., Ph.D.—Cephalon ($47,779,591) and Viropharma ($5,218,781); Alexander Rich, M.D.—Alkermes ($37,106,850) and Repligen ($7,242,625).

Information and data shown, although believed accurate, are not guaranteed. Neither the editors nor publisher shall be liable for any inaccuracies. The shares were priced on March 1, 2000. Information on stock holdings was obtained from January 2000 Disclosure CD-ROM and Edgar-Online database.

NAME

COMPANIES

AMOUNT

William K. Bowes, Jr. Amgen, Xoma, Lynx $686,398,793
Phillip Frost, MD Ivax $642,434,166
David M. Goldenberg, MD, ScD Immunomedics $415,064,144
Lindsay A. Rosenwald, MD Avax, Biocryst, Genta, Interneuron, Neose $336,387,890
Gordon Binder Amgen $308,447,899
William A. Haseltine, PhD Human Genome Sciences $284,014,797
William H. Gates III ICOS $281,135,118
Laurence Jay Korn, PhD Protein Design Labs $215,209,878
Samuel Waksal, PhD Imclone Systems $180,862,974
William J. Rutter, PhD Chiron $176,554,631
J. Craig Venter, PhD PE Corporation (Celera and Biosystems) $167,968,454
Elazar Rabbani, PhD Enzo Biochem $149,897,868
Franklin H. Top, Jr., MD MedImmune $144,179,364
Robert D. Shapiro Monsanto $141,654,092
Orrie M. Friedman, PhD Genome Therapeutics $124,717,648
John W. Holaday, PhD Entremed $123,083,400
George B. Rathman, PhD ICOS $119,277,145
Paul J. Maddon, MD, PhD Progenics Pharmaceuticals $115,592,980
Leonard S. Schleifer, MD, PhD Regeneron Pharmaceuticals $110,782,202
Phillip A.Sharp, PhD Biogen $100,817,708
Andrew E. Senyei, MD Corixa $100,462,478
Raju S. Kucherlapati, PhD Cell Genesys, Millennium $100,003,576
Frank D. Lee, PhD Millennium Pharmaceuticals $97,505,455
Radoje T. Drmanac, PhD Hyseq $95,307,993
Randal W. Scott, PhD Incyte Pharmaceuticals $94,984,976
Joshua S. Boger, PhD Vertex, Millennium $87,180,604
Robert I. Levy, PhD Immunex $87,050,670
William H. Rastetter, PhD IDEC Pharmaceuticals $85,283,672
Mark H. Skolnick, PhD Myriad Genetics $81,004,965
Endre A. Balazs, MD Biomatrix $75,134,309
Paul Schimmel, PhD Alkermes, Repligen $69,900,058
Leonard Bell, MD Alexion Pharmaceuticals $67,434,675
Ronald J. Brenner, PhD Cytogen $61,483,158
Milan Panic ICN Pharmaceuticals $61,159,228
Craig A. Rosen, PhD Human Genome Sciences $59,990,607
Frank Baldino, Jr., PhD Cephalon, Viropharma $52,998,372
Michael L. Riordan, MD Gilead Science $50,489,868
P. Roy Vagelos, MD Regeneron Pharmaceuticals $49,323,327
Richard F. Selden, MD, PhD Transkaryotic Therapies $45,888,887
Louis R. Bucalo, MD Titan Pharmaceuticals $45,810,672
Claude H. Nash, PhD Viropharma $45,524,625
Alexander Rich, MD Alkermes, Repligen $44,349,475
Philip J. Whitcome, PhD Avigen $43,289,659
Sol J. Barer, PhD Celgene $41,551,098
Stephen A. Sherwin, MD Cell Genesys $40,750,121
John S. Patton, PhD Inhale Therapeutics $39,029,848
Alejandro Zaffaroni, PhD Alza $36,411,645
Anthony B. Evnin, MD Triangle Pharmaceuticals $32,678,686
E. Rolland Dickson, PhD NeoRx $26,671,190
Walter Gilbert, PhD Myriad Genetics $25,913,404
John C. Martin, PhD Gilead Sciences $25,193,034
Steven Gillis, PhD Corixa $23,209,673
Edward E. Penhoet, PhD Chiron $22,986,273
Solomon H. Snyder, MD Guilford Pharmaceuticals $22,435,242
John Monahan, PhD Avigen $21,838,192
Stanley Crooke, PhD, MD Isis $21,320,432
Stephen R. Squinto, PhD Alexion Pharmaceuticals $20,841,975
Joseph A. Mollica, PhD Pharmacopeia $20,567,319
Charles J. Homcy, MD Cor Therapeutics $19,850,269
J. Leighton Read, MD Aviron $19,732,596
Edward R.Gubish, PhD Entremed $18,092,250
Joseph C. Hogan, Jr., PhD ArQule $17,959,961
John F. Tallman, PhD Neurogen $16,393,986
Ronald W. Pero, PhD Oxigene $16,042,500
Daniel J. Levitt, MD, PhD Protein Design Labs $15,505,142
Charles E. Bugg, PhD Biocryst Pharmaceuticals $14,793,948
David A. Scheinberg, MD, PhD Progenics Pharmaceuticals $14,469,995
Gail K. Naughton, PhD Advanced Tissue Sciences $13,695,000
Stephen A. Roth, PhD Neose Technologies $13,565,057
Calvin B. Harley, PhD Geron $13,050,525
Philip Leder, MD Genome Therapeutics Inc $12,801,036
James C. Blair, PhD Amylin Pharmaceuticals $12,097,472
Gillian E. Francis, DSc Valentis $11,406,506
Richard A. F. Dixon, PhD Texas Biotechnology $11,128,443
Thomas H. Fraser, PhD Diacrin $11,074,567
Kenneth G. Kasses, PhD Genta $11,006,606
Carl C. Icahn Cadus Pharmaceutical $10,943,452
Paul A. Bartlett, PhD Pharmacopeia $10,351,836
Alan C. Sartorelli, PhD Vion Pharmaceuticals $10,322,017
David T. Rovee, PhD Organogenesis $9,491,163
Arthur P. Bollon, PhD Cytoclonal Pharmaceuticals $9,423,620
David H. Katz, MD Avanir Pharmaceuticals $9,091,099
Sterling K. Ainsworth, PhD Napro Biotherapeutics $8,755,456
Colin Goddard, PhD OSI Pharmaceuticals $8,601,079
Robert J. Israel, MD Progenics Pharmaceuticals $8,026,703
Stelios B. Papadopoulos, PhD Diacrin $3,662,600
Kathleen P. Mullinix, PhD Synaptic Pharmaceutical $3,377,692
Sheldon S. Hendler, MD, PhD Vyrex $3,252,781
John M. Lambert, PhD Immunogen $2,948,893
Dale G. Ando, MD Cell Genesys Inc $2,898,679
Richard A. Kenley, PhD Amylin Pharmaceuticals $2,668,286
James R. Rusche, PhD Repligen $2,651,480
Melvin Perelman, PhD Inhale Therapeutics $2,569,849
Robert C. Bishop, PhD Autoimmune $2,315,021
William P. Tew, PhD Chesapeake Biological Labs $2,286,272
Richard P. Schwarz, PhD Texas Biotechnology $2,280,441
Eugene A. Bauer, MD Connetics $2,254,079
Stanislaw M. Mikulski, MD Alfacell $2,233,080
Marc E. Lanser, MD Boston Life Sciences $2,171,157
Kurt C. Gunter, MD Transkaryotic Therapies $2,169,591

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