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Methyl p-Hydroxybenzoate, Methylparaben, methyl p-oxybenzoate

Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Food Additives (uses other than as flavouring agents) Database

Prepared at the 51st JECFA (1998), published in FNP 52 Add 6 (1998) superseding specifications prepared at the 44th JECFA (1995), published in FNP 52 Add 3 (1995). Group ADI 0-10 mg/kg bw for ethyl, methyl and propyl p-hydroxybenzoate, established at the 17th JECFA in 1973.

SYNONYMS: Methylparaben, methyl p-oxybenzoate; INS No. 218

DEFINITION: Chemical names Methyl p-hydroxybenzoate, methyl ester of p-hydroxybenzoic acid

C.A.S. number 99-76-3

Chemical formula C8H8O3

Structural formula 

Formula weight 152.15

Assay: Not less than 99.0% on the dried basis

DESCRIPTION: Almost odourless, small colourless crystals or white crystalline powder

FUNCTIONAL USES: Preservative

CHARACTERISTICS

IDENTIFICATION

Solubility: Slightly soluble in water; freely soluble in ethanol and propylene glycol; soluble in ether

Melting range: 125 - 128 C

Test for p-hydroxybenzoate: Melting range of p-hydroxybenzoic acid derived from the sample is 212-217 C

To 0.5 g of the sample add 10 ml of sodium hydroxide TS. Boil for 30 min and concentrate to about 5 ml. Cool, acidify with dilute sulfuric acid TS, collect the precipitate on a filter, and wash thoroughly with water. Dry in a desiccator over sulfuric acid. Determine the melting range of p-hydroxybenzoic acid so obtained.

PURITY: Loss on drying Not more than 0.5% (over silica gel, 5 h)

Sulfated ash Not more than 0.05%.

Test 2 g of the sample (Method I)

Acidity: Heat 750 mg of the sample with 15 ml of water at 80o for 1 min, cool, and filter. The filtrate should be acid or neutral to litmus. To 10 ml of the filtrate add 0.2 ml of 0.1 N sodium hydroxide and 2 drops of methyl red TS. The solution should be yellow without even a light cast of pink.

p-Hydroxybenzoic acid and salicylic acid: Dissolve 0.5 g of the sample, accurately weighed, in 30 ml of ether, add 20 ml of a 1 in 100 sodium hydrogen carbonate solution, shake, and separate the water layer. Wash the water layer with two 20 ml portions of ether, add 5 ml of dilute sulfuric acid and 30 ml of ether, and shake. Separate the ether layer, and shake with about 10 ml of water. Filter the ether layer, and wash the vessel and the filter with a small amount of ether. Combine the washings and the filtrate, evaporate ether on a water bath, and dry the residue over sulfuric acid to constant weight. The weight of the residue should not exceed 5 mg. Dissolve any residue in 25 ml of water, heat to about 70o, filter, and add a few drops of dilute ferric chloride TS. No violet to reddish violet colour should be produced.

Lead: Not more than 2 mg/kg

Prepare a sample as directed for organic compounds in the Limit Test and determine by atomic absorption spectroscopy.

METHOD OF ASSAY: Weigh, to the nearest mg, 2 g of the dried sample and transfer into a flask. Add 40 ml of N sodium hydroxide and rinse the sides of the flask with water. Cover with a watch glass, boil gently for 1 h and cool. Add 5 drops of bromothymol blue TS and titrate the excess sodium hydroxide with N sulfuric acid, comparing the colour with a buffer solution TS (pH 6.5) containing the same proportion of indicator. Perform a blank determination with the reagents and make any necessary correction. Each ml of N sodium hydroxide is equivalent to 152.2 mg of C8H8O3

source: http://apps3.fao.org/jecfa/additive_specs/docs/6/additive-0720.htm 1jan04

 

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